Quaternary ammonium salts XVIII.* Preparation and relationship between structure, IR spectral characteristics, and antimicrobial activity of some new bis-quaternary isosters of 1,5-pentanediammonium dibromides
نویسندگان
چکیده
Four series of bis-quaternary jV,yV'-bis(alkyldimethyl)-3-X1,5-penta nediammonium dibromides (36 compounds) were prepared. The effect of alkyl chain length change, from 6 to 18 carbon atoms and of the isosteric exchange of methylene group for NCH3, O, S upon characteristic vibrations in IR spectrum region and upon antimicrobial activity against Staphylococ cus aureus, Escherichia coli, and Candida albicans was examined and de scribed. The relationship of antimicrobial activity vs. R shows a nonlinear parabolic course; by isosteric exchange the effectiveness is not affected. The most effective substances are several times more active than the standard benzyldodecyldimethylammonium bromide.
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